|
KMID : 0359320080480010017
|
|
Korean Journal of Veterinary Research
2008 Volume.48 No. 1 p.17 ~ p.25
|
|
|
Evaluation of antitumor, hepatoprotective and antimutagenic potentials of Phellinus gilvus
|
|
Kang Eun-Hee
Kim Kil-Soo
Park Seung-Chun
|
|
|
Abstract
|
|
|
|
This study was carried out to evaluate the antitumor, hepatoprotective and antimutagenic activities on hot water extract of Phellinus gilvus (PGE). Growth of tumor in mice that were orally given 0.25, 0.5, 1.0, 2.0 g·kg?1 dose of PGE was inhibited in a dose-dependent manner (p < 0.05). The hepatoprotective effect of PGE in the carbon tetrachloride (CCl4)-intoxicated rats was studied. In CCl4 + PGE group, PGE was orally administered with 100 mg/kg/day dose 7 days before the treatment of CCl4. The serum activity of aspartate aminotransferase and alanine aminotransferase in CCl4 + PGE group were decreased at a rate of 59.6% and 54.1% compared with those in CCl4 group, respectively (p < 0.05). Also, total cholesterol and triglyceride in CCl4 + PGE group were significantly decreased at a rate of 90% and 73.6% compared with those in CCl4 group (p < 0.05). In the Ames test, we confirmed PGE doesn’t have any activity as a mutant, and PGE showed inhibitory effect against mutagenesis induced by 2-amino fluride and sodium azide in Salmonella typhimurium TA98, TA100 and TA1535 in a dose-dependent manner. From the above results, we may suggest that PGE might have useful as a material for functional food and/or animal pharmaceutics.
|
|
|
KEYWORD
|
|
|
antimutagenic effect, antitumor, hepatoprotective effect, Phellinus gilvus
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|